Dear Savannah, Thank you for your questions. There are no contraindications to getting Botox one week before your total knee replacement. Best of luck to you!
Botox is fixed into the tissues within 24 hours. Effects can take up to 2 weeks to fully kick in; however, there is no risk after at least 24 hours. Potentially some medications used in general surgery could have an effect on botox proteins if it were not bound.
