Can Juvederm go on top of Restylane in the lips?

I had 1 syringe of restylane injected in my lips and the swelling made me look like a deformed duck for more than a week. When it settled down however it was not quite the volume that I'd like t to be (I let it settle for about a month). Could I get 1 syringe of juvederm (since the swelling was so bad with the restylane) injected on top of that next week? Will there be any weird side effects from the restylane still in my lips?

Doctor Answers 14

Juvederm is great for lips

Thank you for your valid question. It is absolutely fine to inject Juvederm after Restylane and I'm sure you will love the results !
When we inject lips, we carefully plan out exactly what the patient wants in the mirror together and only inject  half of what the patient needs so as to allow room for swelling and not to have a week of downtime. Then my patients can return a few weeks  later for the other half.  I also avoid filler types that are known for causing swelling. Other ways of preventing swelling is to inject in a very slow, gentle and meticulous manner so as to avoid any discomfort and also avoid internal bruising which can lead to swelling. Finally, the use of tiny needles that are imported from Germany also prevents swelling. Patients should  avoid NSAIDs, Vitamin E and Omega 3's  for 2 weeks before their injections for the same reasons. By implementing the above techniques, our patients hardly ever have any downtime. 
You may wish to consider the above as you proceed with your upcoming Juvederm injection so as to prevent any renewed swelling.  

Best Wishes in your quest for beautiful lips !
Dr. Anna Petropoulos
Boston's North Shore

Boston Facial Plastic Surgeon
4.7 out of 5 stars 22 reviews

Yes, You Can Combine Fillers

Yes, you can certainly inject different fillers into the same areas. JUVÉDERM and Restylane are both hyaluronic acids and are essentially they same, just processed differently from different companies. Hyaluronic acids tend to attract water, and this may have been the reason for your prolonged swelling. It is rare but does happen and is more of a potential issue when injecting into the tear trough region. Other than the usual potential for bruising and swelling, there should be no other side effects from Restylane injections that would not also occur with JUVÉDERM. Be sure to check with a qualified provider first, and best of luck.

Louis C. Cutolo, Jr., MD, FACS
New York Plastic Surgeon
4.6 out of 5 stars 13 reviews

Juvederm and Restylane

Different injectable fillers can be used together in the lips in certain circumstances including not achieving enough volume or definition with the initial filler used.

J. David Holcomb, MD
Sarasota Facial Plastic Surgeon
4.6 out of 5 stars 31 reviews

Lip filler

When it comes to lips, both products can produce great results. Although you noticed swelling associated with restylane, you should understand that the same swelling (or even greater) can happen with Juvederm when it comes to lip area. Typically it's best to top-up so soon after the initial injection with the same product especially in the fine area such as lips. However, given that both products are hyaluronic-acid, even if Juvederm were to be used in this area, you should not develop any major "weird" side effects from remaining restylane in your lips. Of course, your physician could also consider another option, which is to dissolve the restylane with hyaluronidase and then use a new vial of juvederm. To optimize your results, you should seek an expert board-certified dermatologist or plastic surgeon who has extensive experience with both products. 

Andrei Metelitsa, MD, FRCPC
Calgary Dermatologic Surgeon
5.0 out of 5 stars 13 reviews

Juvederm and Restylane and Lip Injections

Juvederm and Restylane can absolutely be layered on top of each other.  However, generally Juvederm produces more swelling than Restylane.  Be certain to consult a board certified dermatologist with experience with these delicate lip injections before proceeding.  Best, Dr. Green

Michele S. Green, MD
New York Dermatologist
5.0 out of 5 stars 78 reviews

Technical difficulty unpredictable

As anyone with experience who injects these products would know, it is more difficult to inject new material over recounted injected filler.  It does not matter even if they are the same product.  The first time, the tissues are able to accept the filler wherever you inject it.  The second time, as you attempt to inject, it may be deflected by the material which is in place.  It is possible to perform this, but may present some additional technical difficulty for the injector.  It is not possible to predict, however, and it may be no significant problem at all. I prefer the viscosity, and longevity of juvaderm.

Gary Lawton, MD, FACS
San Antonio Plastic Surgeon
4.9 out of 5 stars 136 reviews


Juvederm and Restylane are basically the same product, but processed a little differently. They both can be used together. Remember, lips will initially swell to some degree. Cold compresses after injection can be helpful.

Connie Hiers, MD
San Antonio Plastic Surgeon
4.6 out of 5 stars 13 reviews

Combining restylane and juvederm in the lips

 I often combine two different filler products in the lips. One is more to volumize (eg restylane or juvederm) and the second is to smooth out the finer lines to give the lips a more hydrated and smoother look (eg restylane silk).   It sounds like in your situation, you're wanting a fuller look than what you achieved with one syringe of restylane.  Either using Restylane or Juvederm to add more volume would be an option at this point. 

Young R. Cho, MD, PhD
Houston Plastic Surgeon
4.8 out of 5 stars 38 reviews

Yes you can

You can certainly add a different material though the juvederm may cause more swelling.
The key, I think, is to use a microcannula for the injection rather than a needle. This should result in significantly less swelling and the results you want.  We do this and it is both safer and more comfortable.

Jeffrey H. Spiegel, MD
Boston Facial Plastic Surgeon
4.6 out of 5 stars 65 reviews

Can Juvederm go on top of Restylane in the lips?

Hello Morgan417,

You can place Juvederm on top of Restylane.  The swelling in the lips is more related to the injection and trauma than the actual filler.  Juvederm and Restylane have similar properties. 

I hope this helps and good luck. 

William Marshall Guy, MD
The Woodlands Facial Plastic Surgeon
5.0 out of 5 stars 28 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.