Thanks for your question. I, too, have a shellfish allergy. There is no relationship between Botox and the primary allergen in shellfish, which is iodide. The class of fillers most commonly used, hyaluronic acid based fillers, don't really have allergic potential; hyaluronic acid lubricates all of our joints and is thus a natural component of our bodies. They also don't contain iodide. If you stick with these fillers, I don't think you will have any issues. Nonetheless, if you are still worried a dermatologist or allergist could easily test you prior to treatment if you wanted. Keep in mind there is a difference between an "allergy" and a complication, side effect, intolerance, etc. all of which can happen with fillers. Hope this helps.