If you have an auto immune deficiency disorder can you have Botox to help with sweating?

Hello Valfiggy,

It is unlikely that there would be a direct problem with someone receiving Botox (onabotulinumtoxinA) for hyperhidrosis (increased sweating) who also has a selective IgA deficiency.

However, that said, a few caveats:

Individuals with selective IgA deficiency can still produce IgM, IgG and other antibodies.  It should be understood that using Botox for a medical indication like hyperhidrosis usually requires large doses of Botox to treat the axillae (underarms), palms of the hands and/or soles of feet. Larger doses of Botox increase the risk of developing a Type II allergic response to Botox through the development of neutralizing antibodies (like IgM & IgG).

There is also an understanding that individuals with selective IgA deficiency are more prone to autoimmune diseases later in life in addition to a possible Type I allergic response (anaphylactic reaction) during blood transfusions due to exposure to donor IgA.

Given the above I'd recommend you consult an allergy specialist or rheumatologist prior to receiving medically indicated Botox.

Good luck and be safe!

Hi,
I'm glad you asked this question. Autoimmune disease is so varied but for Botox, I would be concerned if this was neurological in nature affecting muscles (e.g.multiple sclerosis, myasthenia gravis etc.). Some patients with IgA deficiency may suffer from recurrent infections, allergies, and sinus infections. Make sure you are not allergic to the botulinum toxin or the other substances in Botox.
Let your Injector know of your condition.
All the best,
Justin Harper, M.D.