CoolSculpting vs CryoDefine, which one is better?

Hello and thanks for your question.
This answer is not about Cryodefine as I do not know this machine well. 
It is of great concern to us that there are many cheap machines that come on the market and the safety is of concern. 
Also in some non medical clinics, pre and post treatment care is questionable. We have heard terrible stories of people out for a quick buck who push multiple people barely dressed into one room with cheap machines that frankly are dangerous or barely work.  
There are some medical conditions that are higher risks for these treatments. Some clinics use the Coolsculpt name (a trustworthy machine) although the machine is a cheap rip off. 
Other machines use the name Lipo when it is obviously not a Lipo machine. 
Online group voucher offers is not a place to buy medical treatments and the buyer should avoid these.
Remember, cheap is not good when dealing with your health.
Wishing you all the best,
Dr Murray from Absolute Cosmetic Medicine

When it came time for our clinic to decide on a body contouring / cryolipolysis machine we evaluated all of the available evidence and decided on Coolsculpting for a number of reasons. First and foremost, Coolsculpting is safe. Coolsculpting has a “freeze detect” technology that detects if the skin is getting too cold, and automatically shuts down the treatment. I have heard disaster stories of clients undergoing cheaper treatments overseas and having frost-bite from unregulated freezing technology. Secondly, as a medical clinic, we wanted to have the treatment with the most clinical evidence behind it; this is clearly Coolsculpting. Coolsculpting was developed in conjunction with Harvard Medical School and has been the subject of multiple clinical trials in peer reviewed journal articles. Millions of Coolsculpting treatments have been performed worldwide, and the results speak for themselves.
The new Coolsculpting treatment applicators have a temperature of minus eleven degrees, while many other treatments only go down to minus eight or even minus three degrees. The colder the treatment, the quicker the treatment, but also the more fat cells that get damaged and the more effective the treatment.

While I have heard of the benefits of CryoDefine and it's use of two applicators at once, which is fantastic in theory, I can only in good conscious recommend CoolSculpting because the results that I have been able to see have been all they have been hyped up to be. Ask your physician for more information. 

I am not familiar with Cryodefine, but I am very familiar with Coolsculpting, with the multiple safety features of the system, I was involved with Coolsculpting since its inception and launch on the market in 2010. We have our own system as well and we had to for the last 4 years. I know there are now a number of copycats on the market, cheaper and less safe, as we had to treat multiple issues coming from machines that have minimal safety features, but are much cheaper to run and are run by more or less experienced people.
Coolsculpting machines will be usually in Plastic surgery practices, with high safety standards.
Guaranties cannot be offered with any type of treatment, therefore I tend to agree with the opinion of having to wait a minimum of 8 weeks before taking any other step, as each individual will respond differently to different treatments. Based on your personal experience and tissues behaviour, , we can then estimate a bit better how many treatments will be necessary. However, in many cases it can be more than one.
Take care!