The concern about using fillers if one is allergic to bee stings is whether it is safe to use hyaluronidase. The most common fillers (for example, Juvederm and Restylane) consist of hyaluronic acid. These fillers can be dissolved, if needed, by injecting hyaluronidase into the area of the filler. This makes these fillers safer, because they can be reversed in the event of a side effect or if there is a poor cosmetic result. People who are allergic to bee stings may be allergic to hyaluronidase. In clinical practice, the vast majority of people injected with fillers do not require hyaluronidase, because most people are happy with the results and side effects are rare. If I were injecting fillers in a patient with a known allergy to bee stings, I would be conservative, with careful injection technique and using low volumes to begin with. I would try to avoid hyaluronidase if at all possible and I would have epinephrine or an Epi-pen on hand if use of hyaluronidase was absolutely necessary.The other question is how severe is the bee sting allergy? If there is a history of severe reaction or anaphylaxis, the risk is obviously higher.