Pain levels can vary significantly depending on: 1. size 2. location 3. depth 4. proximity to nerves or muscles Removal of a small, shallow lipoma on the back might cause negligible pain. Whereas, a large, deep lipoma over a mobile joint (shoulder) might produce more pain. On rare occasion, lipomas can even wrap deeper under muscle. Your plastic surgeon should be able to examine your lipoma and give you a better idea, although every patient has different pain thresholds. A small lipoma might only require a little Tylenol. A more complicated lipoma might necessitate stronger, prescription strength pain medicine, sometimes even a narcotic-based medicine. If you can immobilize your shoulder, it should help reduce pain and protect while healing, especially during the first couple of weeks. You could try an arm sling, a figure-of-eight brace, or even wrapping your upper arm against your chest/back (around and under the opposite armpit). Hopefully within a couple of weeks you will have significantly less discomfort. However, you will often have some "sensations" as some of the small nerves in the skin regenerate and heal...tiny nerves in the skin are alway cut when the skin is cut. You may experience occasional tingling, pin pricking, itching, aching, burning, etc...often normal sensations as a wound/scar heals.