A breast reduction is often a balance between the patient goals and the limits of anatomy. Your surgeon will know what is necessary with regards to weight resection. Anatomic limits are non-negotiable as a certain amount of tissue must be preserved in order to maintain vascular supply to the nipple areolar complex. This amount tends to rise with the distance the nipple must travel from where it is to its planned destination. Technically speaking, the larger breast (and greater the ptosis) the more tissue that will need to be preserved in order to maintain vascular supply to the nipple areolar complex. Ultimately, you do play a role in the decision making process. The anatomic restrictions are, on the other hand, more rigid. With regards to your specific question, it is difficult to predict the size of safe reduction. However, as stated above, there will be limits based on anatomy. A 500 gm reduction is reasonable and used to represent the minimum standard. From a very large started cup size, a 500 gm reduction will likely leave you larger than a D cup. Thus, in answer to your question, 500 gms resected will not leave you too small (according to your stated goals). It is also important to remember that we deal in weight and volume (which are standardized) whereas "cup size" goals can be extremely variable (depending upon the manufacturer). There is no correlation between cup and grams resected. Much like in augmentation, focus not on the cup but on the look and resolution of symptoms. As always, discuss your concerns with a board certified plastic surgeon (ABPS). Donovan Rosas MD Board Certified by the American Board of Plastic Surgery Member: American Society for Aesthetic Plastic Surgery, American Society of Plastic Surgeons RealSelf Verified Member RealSelf Top 100 RealSelf Hall of Fame