So far, the only ways to increase the breast size reliably and permanently involve a procedure - breast implants or fat grafting to the breast. As yet, there is no other method with creams, pills or other treatment that is safe and effective.
Thank you for the question. No, there is no safe and/or effective method to increase breast size significantly. Be careful about heavily marketed "medication", lotions, and/or nonsurgical modalities that you will read and hear about. Best wishes.