When we graduated medical school, our professors told us "primum non nocere", first don't harm people. I interpret this as meaning that the treatments we give our patients should be safe. I am proud now that the reports of granulomas with Artecoll and Radiance are surfacing that not one single patient of ours has ever been injected with that substance. Now that silicone horror stories are well-known, not one patient has ever been injected with silicone in our office. While many patients will continue to be injected by the newest fillers with non-natural components such as methyl methacrylate beads, plastic spheres, liquid silicone, silicone gels, we will not inject them in our practice, because it simply does not make sense to put a permanent or semipermanent non-biologic material into the face in my opinion. I am impressed with the safety and effectiveness of hyaluronic acid fillers. Prevelle is a lighter hyaluronic acid with a little lidocaine in it for sensitive patients or patients with little or no recovery time. You can see by the posts that occasionally the heavier hyaluronic acids such as the Juvederm series and Restylane or Perlane, wonderful fillers which we use daily, can cause swelling for several days, so this should be factored for patients who are on camera (i.e. newscasters) or have important social obligations immediately following their injections. So while you can argue which is the best filler, please avoid the bad ones.