What a great question. Although the knees are not the most common area requested, we have performed hundreds of treatments on the knee area. We have a couple of different hand pieces that work brilliantly for this purpose. Of coarse the patient must be thoroughly evaluated to determine if they are a good candidate. Then, we can determine the exact right applicator to use. You must have pinch-able fat that we can grab onto. if you do have this pinch-able bulge in the knee area, you would be a good candidate. It is important to remember that this must be fat, and not saggy skin or flabby muscle. CoolSculpting yields smooth wonderful results that look natural. Regarding the calf area, again this depends on what is seen and felt in the evaluation. In the majority of cases, the calf is not an area that is often treated, because it is not displaying a pinch-able bulge of excess fatty tissue. knees, inner and outer thighs, bra bulges, banana rolls, upper and lower abs, love handles, arms and the submentum (double chin) are the absolute best area for treating with CoolSculpting. The results we get are truly amazing.