How Much Does Hyaluronidase Cost?

How much do hyaluronidase injections cost? Is this cheaper than brand name hyaluronic acid injectables like Restylane or Juvederm?

Doctor Answers 4

Hyaluronidase costs

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Hyaluronidase is NOT as filler and should not be confused.

In actuality, it does the opposite of the filler. It is an enzyme that dissolves the hyaluronic fillers. It is an expensive medication even if it is not name brand.

In general, there is no charge if it is used to correct excessive filling by the hyalurinic acids such as Juvederm or Restylane. I generally do not charge, if I feel overcorrection has occurred. However, if this is a patient request or correction of another surgeons technique, I will charge anywhere from $300-$500 in general.

Chicago Plastic Surgeon
4.9 out of 5 stars 86 reviews

Cost of Hyaluronidase

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The vast majority of Hyaluronidase patients are new to my practice.  I typically charge between $4-600 for a Hyaluronidase treatment and half the amount if subsequent treatment visits are necessary.  If one my own patients are in need of this treatment, then I would not charge them.

Provider for hyaluronidase in Los Angeles

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The cost of hyaluronidase will vary depending on the amount used and the areas of treatment. I perform many of these injections on patients who come to my office after injection by others. 

My technique involves Hidef Hyaluronidase injections that are staged over a few weeks. Precision is much better than bulk reduction. 

Products used include Hyaluronidase and Hylenex. It is important to titrate the dose based on the type of filler injected. 


Raffy Karamanoukian, Los Angeles 

Raffy Karamanoukian, MD, FACS
Los Angeles Plastic Surgeon
4.8 out of 5 stars 95 reviews

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Hyaluronidase for HA Mishaps

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Hyaluronidase is not used as a filler or for cosmetic enhancement. It is an enzyme which breaks up and dissolves the hyaluronic acid found in Juvederm and Restylane. Thus, it is used when excessive hyaluronic acid is injected, or misplaced in the skin. It is a great eraser and can literally be face saving in the event of the rare complication of vascular necrosis ( the blood flow is compromised by the filler and the tissue dying).

I personally have not found the need to use it, (yet!) but would not charge the patient if I did. My feeling is that other physicians would do the same.

Arnold R. Oppenheim, MD
Virginia Beach Dermatologist

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.