How long does it take for Hyaluronidase to work?

Hyaluronidase can begin to work immediately.  If I am helping a patient deal with symptoms that cause discomfort (eg nerve or vascular compression/occlusion with fillers) then I will continue to add Hyaluronidase every 10-30 min until I get symptom relief.  If I am doing this to help even out an unintended injection result, then I tend to be more conservative and have the patient return the next day or two and continue to make adjustments until the desired result is achieved.

Hyaluronidase can actually work within hours.  Most of the impact will seen over the first 48 hours with a small amount of change seen over a period of 2 weeks as your body absorbs the filler.  Best Dr. Anil Shah

Hyaluronidase can effectively reduce unwanted hyaluronic acid facial filler.  The effects can be seen early in the first 48 hours, and with additional time thereafter you can see the final results. Raffy Karamanoukian, MD Los Angeles

In my experience 2 to 3 days. It varies from individual to individual and also depends on the dose. Try to undergo small amounts of injections to see if it works well for you. It can sometimes work too well and absorb all the Hyaluronic Acid. If that is your intent, then go ahead. However, sometimes patients like the results but have a small bulge which needs to be flattened.In that situation it is better to start with small amounts and then titrate it based on the response.
Regards

Much of hyaluronidase will take action within the first 24 hours of injection. Additional absorption can occur over the remaining 2 weeks. Keep in mind swelling, irritation at the injection site and some pain can occur when injection of hyaluronidase. Be sure to consult with an experienced practitioner before having your filler dissolved.