How Long Does It Take for Hyaluronidase to Work?

How long does it take for the hyaluronidase to dissolve the hyaluronic acid based filler?

Doctor Answers 7

Hyaluronidase time of onset

A couple things about hyaluronidase

1. It takes 2-3 days to dissolve the filler

2. It may take an additional 2 weeks for absorption of filler/hyaluronidase to occur

3. It may take a couple more months for the skin and local swelling of tissue to resolve

Most of the effect is seen immediately but then the healing process may take some longer time to get rid of the swelling etc..

Denver Oculoplastic Surgeon
4.9 out of 5 stars 9 reviews

Hyaluronidase work early (within 48 hours) and quickly

Hyaluronidase will start to work within 48 hours and have an effect lasting 2 weeks - additional treatments of hyaluronidase can be given within 2 weeks of the first treatment for additional dissolution remaining Juvederm or Restylane.

Hratch Karamanoukian, MD, FACS
Buffalo Phlebologist
4.8 out of 5 stars 41 reviews

Hyaluronidase timing

Hyaluronidase can begin to work immediately.  If I am helping a patient deal with symptoms that cause discomfort (eg nerve or vascular compression/occlusion with fillers) then I will continue to add Hyaluronidase every 10-30 min until I get symptom relief.  If I am doing this to help even out an unintended injection result, then I tend to be more conservative and have the patient return the next day or two and continue to make adjustments until the desired result is achieved.

Young R. Cho, MD, PhD
Houston Plastic Surgeon
4.8 out of 5 stars 37 reviews

Hyaluronidase works almost instantly

The effects of hyaluronidase on hyaluronic acid can be seen almost instantly.  Maximum results are achieved in approximately 2-3 days.  This is a great treatment to remove unwanted filler.

Gregory Pippin, MD
Metairie Facial Plastic Surgeon
4.2 out of 5 stars 7 reviews

Restylane and Juvederm

Hyaluronidase works in just a few days to dissolve hyaluronic acid filler.  You might get some redness and swelling after the hyaluronidase injections but overall this is a safe and effective way to removed unwanted filler.

Patricia Farris, MD
Metairie Dermatologic Surgeon


In my experience 2 to 3 days. It varies from individual to individual and also depends on the dose. Try to undergo small amounts of injections to see if it works well for you. It can sometimes work too well and absorb all the Hyaluronic Acid. If that is your intent, then go ahead. However, sometimes patients like the results but have a small bulge which needs to be flattened.In that situation it is better to start with small amounts and then titrate it based on the response.


Tanveer Janjua, MD
Bedminster Facial Plastic Surgeon
5.0 out of 5 stars 107 reviews

Hyaluronidase Wydase for facial fillers

Hyaluronidase can effectively reduce unwanted hyaluronic acid facial filler.  The effects can be seen early in the first 48 hours, and with additional time thereafter you can see the final results. Raffy Karamanoukian, MD Los Angeles

Raffy Karamanoukian, MD, FACS
Los Angeles Plastic Surgeon
4.8 out of 5 stars 94 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.