Cause of Allergic Reaction to Restylane?

Does developing granulomas a month after Restylane injections indicate an allergic reaction to the protein that binds it?  Would Radiesse be a safer alternative?

Doctor Answers 4

A granuloma is not an allergy

{{ voteCount >= 0 ? '+' + (voteCount + 1) : (voteCount + 1) }}

Granulomas are when the body reacts to a substance and considers it foreign material. The is an intense inflammatory response, but not an allergy. This creates redness and swelling. Steroids are usually given to reduce the swelling. Sometimes, dissolving the filler with hyaluronidase will resolve the problem too.

You can form granulomas with any filler. Also, it doesn't happen every time you get the same filler.

Interesting, I was told that Radiesse forms the least amount of granulomas of the fillers, but I can't substantiate that. Radiesse does form more nodules than other fillers, which is bumps that are not swollen and do not hurt.

I don't have any personal experience with the granulomas, but have been to several meetings where they were discussed.


Panama City Facial Plastic Surgeon
4.9 out of 5 stars 75 reviews

Cause of Allergic Reaction to Restylane?

{{ voteCount >= 0 ? '+' + (voteCount + 1) : (voteCount + 1) }}

Thank you for your question. It’s very rare to have an allergic reaction to hyaluronic acid fillers, such as Restylane or Juvederm. Your reaction is most likely due to the ingredients in hyaluronic acid products and this is very common. However, I do recommend having a follow up with injector to have this evaluated and treated. Best of Luck!



Hardik Soni, MD (not currently practicing)
Summit Emergency Medicine Physician

Allergic to Restylane?

{{ voteCount >= 0 ? '+' + (voteCount + 1) : (voteCount + 1) }}

We have not had a single patient in our practice present with the symptoms you describe.  This is most likely because a reaction specifically to the ingredients in hyaluronic acid products such as Restylane and Juvederm is very uncommon.

With that said, and given your history, we agree that Radiesse is a viable alternative for you to look into.

Harold J. Kaplan, MD
Los Angeles Facial Plastic Surgeon
4.4 out of 5 stars 7 reviews

Granuloma formation rare after Restylane or Juvederm filler injection

{{ voteCount >= 0 ? '+' + (voteCount + 1) : (voteCount + 1) }}

True skin allergic reaction to hyaluronic acid fillers such as Restylane or Juvederm is exceedingly rare. Granuloma formation can seldomly happen after hyaluronic acid injection and often is attributed to less than perfect hygiene skin preparation prior to injection rather than the hyaluronic acid itself.

William Ting, MD
Bay Area Dermatologic Surgeon
4.5 out of 5 stars 14 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.