Is it safe to take Propecia with Gilbert Syndrome?

Question

I have Gilbert Syndrome and I am jaundiced as a result of it. However, I have no liver damage as seen by a biopsy. Am I more likely to get side effects with Finasteride with Gilbert Syndrome, such as Gynecomastia or is it unsafe for me? Or, is finasteride safe for patients with Gilbert Syndrome?

Marco Barusco, MD · Answer

Hello,

Thank you for your question. Gilbert Syndrome, while causing mild jaundice, does not typically affect liver function or the metabolism of medications like finasteride. Since your liver biopsy shows no damage, finasteride is generally considered safe for individuals with Gilbert Syndrome.

However, as with any medication, side effects such as gynecomastia are possible, though they are rare and not directly linked to Gilbert Syndrome. I recommend discussing your concerns with your prescribing physician, who can monitor you closely and ensure the treatment is suitable for your individual circumstances.

Best regards,
Dr. Marco Barusco

Audrey G. Bauer, MD · Answer

The underlying way your body metabolizes finasteride is through your liver but unless you have known liver damage there should be no effect on how you process your finasteride and no need to avoid it or adjust dosing.  Gilbert Syndrome is related specifically to how your liver processes bilirubin and is NOT at all related to the cytochrome P450 system, which is the system for metabolizing drugs.  Therefore you are not more likely to have problems with finasteride due to your Gilbert Syndrome.  Hope that helps.

Is it safe to take Propecia with Gilbert Syndrome?

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Is it safe to take Propecia with Gilbert Syndrome?

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