How long does it take for Hyaluronidase to dissolve lumps?

Longterm filler problems include migration, edema, and nodularity. Filler migration and permanence is a very common problem because there are many different types of HA fillers on the market and each is specified for a specific part of the face. Use of highly cohesive fillers on thin skin may cause swelling and nodularity. If patients have filler migration or nodules, we recommend a combination approach of filler reversal with enzymes Hylenex and Hyaluronidase in different strengths to dissolve the filler. We may also need to add Kenalog to the mix in order to reduce fibrous tissue. If the filler does not dissolve, it either means the filler is not HA material or we need more enzyme. The HA reversal can be combined with other lasers and skin treatments at the same time, and it usually (usually) does not affect adjacent tissue.

Best,
Dr. Karamanoukian
Realself100 Surgeon

Good Afternoon and thank you for your question.  Hyaluronidase typically takes 24 hour to dissolve however it does show initial swelling immediately after injected.  I advise all of my patients to wait 24-48 hours in order to allow the product and swelling to subside, then I have them return back to my office to evaluate the results. In some cases more than one session of injection may be necessary.  Best of luck to you.

Hi Bunnyglw, Optimum action of Hyaluronidase would be within 3-6 hours after injection. It should clear maximum of 2 days. It would be best to inject at the center of the filler to be dissolved and should be done in increments. There might be a tendency to swell.All the best, Justin Harper, M.D.