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Extraordinary pain with hyaluronidase? I had too much Voluma in my cheeks about a month ago.

allisoncarmenMay 25, 2018
Because I am abroad for awhile, I went to a reputable foreign doctor for hyaluronidase. I've had Vitrase and Hylenex before w/ minimal pain, but these injections were SO painful. They burned horribly. 2 hours later, the areas are warm and tingly. Is there a difference between pure hyaluronidase and Vitrase/Hylenex? What might account for the difference in my experiences w/ hyaluronidase. I'm concerned I've done serious damage.

Answers (1)

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Jason Emer, MD profile photo
Dr. Jason Emer, MD
Dermatologic Surgeon, Board Certified in Dermatology
4.7 | 522 Reviews
Answered on May 28, 2018
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David S. Felder, MD

I have been using hyaluronidase for over 20 years and have not seen any problems if it is done correctly. If you do not like the filler placed in this area, it is very simple to remove it, as long as the filler was a hyaluronic acid dermal filler.

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Onir Spiegel, DDS, PhD

I suppose if you inject enough hyaluronidase to dissolve HA following a traumatic experience the material can dissolve your own HA.  It should not dissolve any of your other tissues.  I hope that's helpful to you. Best from Boston, Dr. Onir

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Jose Barrera, MD

Hyaluronidase is the enzyme that breaks down hyaluronic acid. Although there are different types of hyaluronidase, generically its the same compound. Commercially it is available as Vitrase or Hyalase. There are different unit amounts per preparation. An experienced injector will be able to ...

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Raffy Karamanoukian, MD, FACS

Filler complications are common and can cause emotional distress and in some cases, physical deformity. Swelling, lumpiness, and uneven facial volume are just a few of the complications associated with hyaluronic acid fillers. Our office is a global center of excellence for the management of...

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Justin Harper, MD - Account Suspended

Hi ajhxspdr,We usually use full strength hyaluronidase injected into the center of the lump. Hyaluronidase is injected in increments and may be done in 4-5 visits. If granuloma is suspected, you may need steroids. All the best, Justin Harper, M.D.

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Judith F. Rubin, MD

Hyaluronidase removes synthetic HA's very well but it also removes natural Hyaluronic Acid from the tissue. This HA is usually replaced my the body in just a few days. You will not lose skin tissue in the area that the enzyme was injected and you should be fine ( absent the injected HA)in just a...

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