Thank you for your question. I'm sorry to hear about your struggles with acne. You can restart Accutane therapy, however, since you already experienced the side effect of hair loss, then the chances of you experiencing the same side effect with another course of Accutane is high. There are other alternative treatment options that are available such as combination therapy with oral antibiotics and topical medications, light therapy, chemical peels, facials, etc. After one course of Accutane, the skin is more sensitive and may be more susceptible to topical and oral therapy. I highly recommend you consult with a board certified dermatologist to have your skin evaluated and to discuss treatment options that best suits your skin and needs. Take care and good luck.