Can I combine tretinoins ( retin-a) with isotretinoins and achieve good results?

If someone is taking oral isotretinoin for acne, they will not need to use tretinoin or any other topicals. In fact, using tretinoin during that time would make their skin extremely irritated and red given the fact that isotretinoin considerably dries out the skin. Tretinoin would only increase that.I hope this answer is helpful! Best of luck.

You did not say what you were wishing to treat. Isotretinoin (Acutane) has been used to treat Acne, though I know of almost no one who uses it any longer because of side effects. Retina-A is used for skin rejuvenation. You need to see a very experienced physician (plastic surgeon or dermatologist) who can evaluate your skin and decide what is best for you.