Does Sculptra collagen ever leave? It's been 2 years since I had 4 vials spread out over the course of 3 months.

Collagen does last a long time, but your face will undergo aging and lose collagen.  A photo would help to suggest options to rebalance the bottom heavy look.  Example Botox in the masseter region can help narrow the outer lower face, Perlane/Volume in the cheeks can bring more width to the midface.

I suggest Thermage and venus legacy treatments to help tighten the tissue and improve the swelling/laxity.  Also an in person examination would be best, Sculptra rarely causes "swelling" or heaviness.  It gives a very natural lift with subtle changes in my hands.  Best, Dr. Emer.

I have seen results from Sculptra last 2-4 years, but it generally does eventually go away.  It is important, when treating the face with Sculptra, not to place the product too low because you can get the bottom heavy face that you describe.  Hyaluraonidase will not break Sculptra down.  It is possible that 5-FU or a steroid injection could help in some patients.  

An examination would provide a much better answer as to the preferred treatment plan.  The simple answer is that collagen produced by Collagen takes time to be broken down by the body, hence the necessity of seeing an experienced injector to begin with.  Sculptra is best injected in a manner that emphasize the upper cheek area as opposed to the lower face.  At this point,some form of lfting procedure might be most appropriate.

I have injected 100s of patients with Sculptra but have never found Sculptra to last "forever". I have seen patients have it last 2-3 years; but usually even when it is lasting a long time, they want to come in and have a "booster" vial(s) around 18-24 months. There is not a true "Sculptra Reversal" injection (like Wydase to Restylane). I would be cautious with off-label injections. Perhaps consider VERY carefully performed lower face liposuction, or a "lifting" surgical procedure. 3-4 pictures of your area of concern are also helpful in these forums. Best of luck to you.

You still need to be seen in person... I might try hyalurondiase dissolver injections...............

You can try other procedures that are lifting such as fillers in the upper part of the face.  Skin tightening such as the Infini will also help.  You can't really get rid of collagen easily.