Can Efudex cause permanent hair loss or affect hair regrowth?

Question

I’m a middle aged male considering using Efudex on my face to treat sun damaged skin. Can Efudex cause permanent hair loss or affect hair regrow? I do not want to permanently lose hair on my face particularly in the beard area. Thank you.

Anna Chacon, MD, FAAD · Answer

Efudex (fluorouracil) is a topical chemotherapy cream commonly used to treat pre-cancerous and cancerous skin lesions, including actinic keratosis and superficial basal cell carcinoma. When applied to the face, it's natural to be concerned about potential side effects, including hair loss.

Hair Loss Risk: While Efudex primarily targets abnormal skin cells, it can sometimes affect hair follicles in the treated area. Temporary hair thinning or loss in the application site, such as the beard area, might occur due to the irritation and inflammation caused by the treatment.

Permanence of Hair Loss: Permanent hair loss from Efudex is uncommon. Most hair regrowth typically occurs after the skin has healed from treatment. However, individual responses can vary, and factors such as the extent of the treatment area and the duration of use may influence outcomes.

Consultation and Monitoring: It's important to discuss any concerns with your dermatologist before starting treatment. They can provide guidance tailored to your specific condition and monitor your response to the medication. If hair loss occurs, they can suggest measures to support regrowth once treatment is complete.

By working closely with your dermatologist and following their recommendations, you can manage the treatment effectively while minimizing potential side effects.

Can Efudex cause permanent hair loss or affect hair regrowth?

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