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periorbital fat atrophy has been described with Latisse usage and can cause this to occur. I would stop using the medicine and see a board certified dermatologist or plastic surgeon about replacing the volume loss with an injectable filler like restylane or belotero.
The combination of minoxidil and Latisse has not been studied. I don't advise use of minoxidil on the eyelids.
Thank you for your question in regards to Latisse.Yes, you have to continue using Latisse for lash growth. It is a maintenance application. When you stop using it, your lashes will go back to original length prior to Latisse. To be sure what is best for you, see two or more board-certified...
You want to make sure that you've removed all of your eye makeup before latisse to your dry/damp lashes. Obviously, the latisse will make them wet. Make sure to clean up any excess product with a q-tip. Best, Dr. Nazarian