Yes, Accutane can cause fatigue. If you have never experienced this before, then most likely it is a side effect of the medication in your case. I would recommend that you make an appointment to see your doctor and discuss your symptoms with him. Sometimes changing the time of day when you take the medicine, such as nighttime vs morning, can make a difference; lowering the dose can help too. As always, make sure to stay hydrated. If you continue to feel fatigued despite these measures and it is interfering with your daily activities then you should consider stopping the medicine. But again, not without discussions with your doctor. Good luck. Be well.
Fatigue and Isotretinoin
Fatigue is a known side effect of this medication. While it's not extremely common, it is something that we always monitor for during follow-up visits while a patient is on Isotretinoin. Make sure that you are staying well hydrated, as dehydration can make a person feel worn-down or tired. Regardless, please check in with your prescribing physician and review your symptoms with them. It could require an adjustment for your dose or closer monitoring. Good luck!