Thank you for your question ipach71. Botox is a purified protein used to treat certain wrinkles on the face. The marionette lines are those we see with age that go from the corners of the mouth to the jawline.First Botox comes in units, not syringes. While Botox is most commonly used in the upper face a small amount of Botox can be injected in the lower face in the DAO muscle which pulls down the corner of the mouth. This will elevate the corners of the mouth by about one millimeter. This may enhance the result of filler treatments, which are best for these lines.Fillers such as Voluma, Juvederm, and Restylane work well to address volume loss in the cheeks, marionette lines, and tear troughs, respectively. I prefer treating marionette lines with Voluma in the upper cheek and a skin tightening treatment and later assessing if Juvederm would provide further benefit in the nasolabial folds and/or marionette lines.Finally, treatments are not done by years. Typically people will enjoy the results of Botox for three to four months. With fillers, although this is generally longer, it is more variable. This can range from six months to two years, depending on the location, filler, and the amount used. For example fillers in the lips tend to last less than those on the cheeks. Fillers such as Belotero are very short-lived, while Voluma and Bellafil last longer. Please consult with a doctor for specific recommendations. Good luck!