Our bodies produce collagen all along, but at a varying pace. At the same time there is the process of collagen breakdown from a natural enzyme in our bodies called collagenase.When your're young, the balance stays fairly consistent. But as you age, the balance shifts and after a while you have more collagen breakdown than production.You can actually see this shift begin in your 30's and it becomes more apparent the older you get.Absolutely lifestyle and sun exposure play a factor in the accelerated breakdown since UV rays, poor diet, smoking and alcohol have negative effects on your skin.As doctors, we can tell you to stay out of the sun and not smoke or drink, but age will eventually throw off the collagen build-breakdown cycle even if you take all the precautions and stay incredibly dedicated to a healthy life style.Interrupting that collagenase action with stimulatory fillers can slow things down considerably. That's where Sculptra can have a profound impact - and more so with the 35-40 set since stimulation of collagen works best around that time. Yes, those older can benefit, but it takes longer and it takes more product.Cosmetic Fillers Science is an interview video that may help explain this concept in more detail.