Can retinoids cause vitiligo?

Question

Hello, can using topical retinoids be a risk factor in causing vitiligo? How about bleaching agent likes benzoyl peroxide or even lightening agents such as azelaic acid?

Anna Chacon, MD, FAAD · Answer

When considering the potential effects of topical retinoids, benzoyl peroxide, or azelaic acid on skin conditions such as vitiligo, it's important to understand their primary uses and mechanisms of action.

Retinoids are primarily used to treat acne, photoaging, and other dermatological conditions by promoting cell turnover and reducing inflammation. There is no evidence to suggest that retinoids cause vitiligo, which is an autoimmune condition characterized by the loss of pigment-producing cells.

Similarly, benzoyl peroxide is a common acne treatment that works by killing bacteria and reducing inflammation. It does not have a known association with causing vitiligo.

Azelaic acid is used for its anti-inflammatory and skin-lightening properties, often in the treatment of acne and rosacea. While it can lighten hyperpigmented areas, there is no evidence to suggest that it causes vitiligo.

Overall, these agents do not appear to be risk factors for developing vitiligo. If you have concerns about changes in your skin pigmentation, it's best to consult a dermatologist for a thorough evaluation and personalized advice.

Can retinoids cause vitiligo?

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Can retinoids cause vitiligo?

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