Both Plavix and aspirin have an effect on blood coagulation which lasts for 7-10 after stopping the medication. Before undergoing any procedure, especially an elective surgical correction including an upper eyelid lift (blepharoplasty), you would need to have discontinued those medications to avoid bleeding problems.Prior to undergoing the procedure, you should have medical clearance from your primary physician or cardiologist and a full discussion about the risk factors of discontinuing them, whether it is appropriate to be off the medications, and information about whether you need any other medications or precautions in the immediate pre and post-operativeperiod. There needs to be excellent communication between that physician and your plastic surgeon prior to any procedure.Robert Singer, MDFACSLa Jolla, California