Cold sores typically do not form after Juvederm injections. But, in patients that have a history of cold sores, doctors often prescribe Valtrex, because it will lessen the likelyhood of developing a cold sore and shorten the duration of having the cold sore. I was at a cosmetic surgery conference this past year and raised the question, "what do doctors typically do for prophylaxis against cold sores" and there was no consistent answer - some doctors prescribe Valtrex before, some the day of and some for several days after. The bottom line though, is that if you start to feel a cold sore develop, and you use Valtrex as soon as possible, it should decrease the severity and longevity of the cold sore.