Accutane is an oral form of vitamin A. It reduces the amount of oil released by oil glands in your skin, and helps your skin renew itself more quickly. As it dries out oil glands, patients experience severe dryness of their skin and mucous membranes. Accutane is used to treat severe nodular acne. It is usually given after other acne medicines or antibiotics have been tried without successful treatment of symptoms. Because it can cause severe, life-threatening birth defects, many doctors are hesistant to use it. Never use Accutane if you are pregnant or planning pregnancy. Women of child-bearing potential must agree in writing to use two specific forms of birth control and have regular pregnancy tests before, during, and after taking isotretinoin. Since their has been some links to depression, crohns disease, liver disease and other rare effects, many lawsuits have arisen in the USA which is another reason it is very difficult to give. Accutane is available only under a special program called iPLEDGE in the USA. Overall, in the right hands, it is a great medication and if used properly, it will clear acne for life in 90-95% of cases. For the best results, please consult a board certified dermatologist with experience with severe acne.