Hi and thanks for your question. Bra size is difficult to predict following a breast reduction. This is because bra size isn’t standardized. In addition, the shape of the breast may change after surgery which may have a different fit into a particular cup size. In general, approximately 50% of the breast volume can be safely removed during a breast reduction. For a large-breasted woman, this will lead to a marked change.A visit to a plastic surgeon's office will help you to understand if you're a candidate for the procedure, and what aesthetic outcomes are realistic in your particular case. In order to get a qualified, ethical, and expert opinion on your surgical options and expectations, always schedule an in-person office consultation with a plastic surgeon certified by the American Board of Plastic Surgery. Best of luck, Keith M. Blechman, MD New York, NY