In general, a medium depth chemical peel would be needed to help improve vertical lipstick bleeding lines. This kind of peel can be effective, but like true dermabrasion, is an aggressive procedure that involves prolonged healing and real downtime and the risk of permanent hypo or hyperpigmentation and even scarring. I have been treating vertical lip lines with fillers sor more than three decades, since the early days of the use of the original collagen filler, Zyderm I. Today, we are fortunate to have more sophisticated hyaluronic acid fillers, such as Belotero Balance, which I would use for this purpose in my Upper East Side Manhattan office and Teosyal Redensity II (which I would use in my Israel satellite facility where a far greater number of regulatory agency approved fillers are available). Both have little to no tendency to give rise to the unwanted, bluish Tyndall Effect when injected superficially within the delicate tissue around the mouth.I would not use a permanent filler, such as Artefill, silicone or Bioalcamid, as these have been associated with the early and late (as many as twenty years later) formation of disfiguring nodules and granulomas that are very difficult to treat. Furthermore, unlike with the use of temporary or semipermanent fillers, permanent fillers cannot be dissolved or easily removed and in my opinion would be a poor and risky choice, particularly for this region.Fractional microneedle resurfacing, about which you can learn more in the archives of Realself, can serrver an additional procedure following the use of an injectable filler to promote new native collagen synthesis (neocollagenesis), which can even further smooth and prolong the effects of filler treatment.