Can this be reduced with Botox? Lower face near mouth

It's difficult to tell from the photo if the area that concerns you is muscle related or a fat deposit. If it is muscle related, Botox is not recommended as it could inadvertently impact your smile. If it is a fatty deposit it may be improved with liposuction, but truly it may be better to leave it alone.

Hi funhoney. This is definitely not the buccinator and is most likely the risorius, although it would be easier to tell if we saw dynamic motion. Nonetheless, I would STRONGLY recommend against getting any botox to decrease this area as muscles in this area are highly interdigitated, meaning that the botox can inadvertently affect another muscle, and the muscles in this area are what affect your smiling. You are almost certain to develop some kind of smile asymmetry if you go after this with botox. I would leave it alone.

Targeting the buccinator muscle for this isn't advisable. It plays an important role in keeping the oral mucosa against the teeth for chewing. If relaxed, it might result in a saggy cheek. Plus, the nearby risorius muscle, which helps pull the corner of the mouth outwards during a smile, might be impacted too.