Thank you for your question didtjwns. Botox comes as a dry powder in a vial and is reconstituted with normal saline per the manufacturer's guidelines. Many offices use preserved saline, which has the advantages of lasting longer and being more comfortable when injected. The composition of 5% dextrose is different from that of normal saline. Saline can also be prepared as D5S, which is normal saline plus 5% dextrose. There are no studies comparing reconstitution of Botox with D5S with reconstitution in normal saline. So we do not know the answer to this question. Any time I do not know the answer to a question like this I always go by the manufacturer's guidelines. This reduces errors and complications. Good luck!
What if Botox was mixed with 5% dextrose solution instead of saline?
Doctor Answers 6
Reconstitution of Botox
Botox mixed with Dextrose solution
In short, if you have had no significant swelling or pain, all will likely be fine. It is unlikely the dextrose will break it down and it will likely last just as long as if it were mixed with normal saline.
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