Bellafill is 20% PMMA in 80% bovine collage, so how many syringes needed just to have PMMA for lifetime?

Question

The 80% Bovine collagen will go one day , all melted the 20% PMMA wont. Is it worth it go get 5x the amount just for PMMA permanent effect ,thanks :)

Anna Chacon, MD, FAAD · Answer

Great question, and I appreciate how thoughtfully you're approaching this. You're absolutely right in noting that Bellafill is composed of 80% bovine collagen gel (which acts as a temporary carrier) and 20% PMMA microspheres, which are non-resorbable and intended to provide long-term support by stimulating your body’s own collagen over time.

Here’s how to think about it:

When injected, the collagen component gradually dissolves over 1–3 months, and the PMMA microspheres remain, encouraging your body to lay down its own collagen matrix.

Because only 20% of each syringe is PMMA, you’d theoretically need five times the volume to reach the equivalent of “1 syringe's worth” of lasting PMMA scaffolding.

However, it's not about volume alone — Bellafill is designed to stimulate your natural tissue response, so clinical results are often greater than the sum of its parts.

In practice:

You don’t typically need to inject 5 syringes just for 1 syringe’s worth of permanent volume, because the collagenesis it triggers continues to evolve over months.

That said, for structural support or larger volume correction, it’s common to layer Bellafill gradually over several sessions — especially in areas like the midface, jawline, or nasolabial folds.

The ideal amount varies based on your goals, facial anatomy, and whether you're building foundational support or refining a surface concern.

My approach is always conservative and customized. A thorough consultation helps determine the right plan, including whether Bellafill or a combination of treatments (like Sculptra, HA fillers, or fat transfer) would best meet your long-term aesthetic goals.

Anil R. Shah, MD · Answer

Hello! My name is Jessica, I am a physician assistant, and one of the providers at Aesthetic Skin in Winnetka and Chicago. Deciding whether to get a larger amount of Bellafill primarily for the permanent PMMA component involves weighing several factors. Since the 20% PMMA is designed to provide long-lasting results, many patients find it worthwhile to invest in more product to achieve the desired effects, especially if they are looking for a longer-term solution. I hope this helps and best of luck!

Bellafill is 20% PMMA in 80% bovine collage, so how many syringes needed just to have PMMA for lifetime?

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Bellafill is 20% PMMA in 80% bovine collage, so how many syringes needed just to have PMMA for lifetime?

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Everything you need to know about Bellafill

Our mission is to create a world where every investment in modern beauty is Worth It.