Oral minoxidil is primarily used for treating hair loss by promoting hair growth and improving blood flow to the hair follicles. There is limited research directly examining the impact of oral minoxidil on collagen production. However, it is generally understood that the primary mechanism of minoxidil is not related to collagen synthesis. PMMA (polymethyl methacrylate) fillers like Bellafill are used for long-lasting facial volume and wrinkle reduction. They work by stimulating collagen production at the injection site, leading to a more prolonged aesthetic effect. Currently, there is no evidence to suggest that oral minoxidil negatively affects the results of PMMA fillers. However, every individual may respond differently to treatments, and factors such as overall health, skin condition, and concurrent medications can play a role. It is always best to discuss your specific situation with your healthcare provider or a dermatologist, who can provide personalized advice based on a comprehensive understanding of your medical history and treatment plan.