Will heavy smoking affect the PRP for hair loss treatment?

Modest5642,While AGA results mainly from the action of DHT on the genetically predisposed follicles. Microvascular changes around the follicles have been observed with increases in vascularization during anagen growth phase. PRP promotes increased vascularization through the action of VEGF. Nicotine in any form is a very potent vasoconstrictor so it's consumption may diminish the benefit of PRP.

While smoking does not specifically affect PRP, the two do not compliment each other.
It is important to remember that male pattern hair loss while hormonally driven is ultimately an issue of vascularity. The goal of PRP is to reverse this relative devascularization through growth factors. The nicotine in cigarettes causes microvascular constriction. Thus smoking and PRP are in direct conflict.
With regards to your specific question, I would encourage smoking cessation. The sooner the better. While there is no empiric data on using the 2 in conjunction, one would logically assume that heavy nicotine exposure is not helping.
As always, discuss your concerns with a board certified plastic surgeon (ABPS).Donovan Rosas MD
Board Certified by the American Board of Plastic Surgery
Member: American Society for Aesthetic Plastic
Surgery, American Society of Plastic Surgeons
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Androgenic alopecia is associated with changes in the microvasculature. These include a narrowing and decrease in the number of blood vessels surrounding the hair follicles. PRP can partially reverse these changes, however the function is diminished with heavy smoking.Jeff Rapaport MD FAADRealself All-star