Hello bebelynn39, thank you for your question! These lines result from decreasing collagen in the skin, a normal part of the aging process. A neurotoxin is usually not the best treatment for this region because it can affect the smile and height of the cheeks. In our practice, we use a multi-modal approach. We recommend to do a series of RF-microneedling treatments to tighten and strengthen the skin, then progress to either PDO smooth threads (not barbed threads) and/or injection of a soft, highly mobile HA filler. The PDO threads will cause the area to produce more collagen, which will lead to impovement of the lines. The HA product can help to plump the skin back up to minimize the creasing of the skin. Best of luck, I hope this helps! Genie Alexander, RN BSN for Anna Petropoulos, MD FRCS at Center for Classic Beauty, Boston & Danvers, MA