What’s another alternative to Sculptra, other than filler, if you have an autoimmune disease like POTS?

Question

Anna Chacon, MD, FAAD · Answer

If you have an autoimmune condition like POTS (Postural Orthostatic Tachycardia Syndrome), it's wise to be cautious with injectable biostimulatory treatments like Sculptra, as they may pose a theoretical risk of immune activation.

Alternatives that are generally considered safer for individuals with autoimmune conditions include:

Platelet-Rich Plasma (PRP): This uses your own blood components to stimulate collagen and improve skin texture. It’s autologous, meaning it carries a lower risk of reaction.

Microneedling with PRP or growth factors: This combination promotes collagen remodeling in a more natural and superficial way, with minimal risk of triggering autoimmune symptoms.

Radiofrequency (RF) treatments or Ultrasound-based therapies (e.g., Ultherapy): These non-invasive technologies stimulate collagen and tissue tightening without the use of injectables or foreign substances.

Topical treatments and prescription-grade skincare: Medical-grade retinoids, peptides, and antioxidants can support skin firmness and volume over time.

It’s always important to consult with both your dermatologist and the physician managing your autoimmune condition to ensure your treatment plan is appropriate and safe.

Ruby Gill, MD · Answer

You are absolutely correct to be concerned about using something that can stimulate your immune system, with your condition. I typically will do a vampire facelift in such cases, this uses your own plasma to stimulate a similar mechanism for collagen production like the sculptra does. It does however take a lot longer to see visible effects (6months+), but it is certainly safer. I have had beautiful outcomes with patients, and in fact sometimes combine PRP with sculptra. Your body will not respond to its own plasma in an immunogenic manner, and it is regarded as a lot safer.

Leonard Grossman, MD · Answer

Sculptra is a biostimulatory filler, which means it creates more volume over a period of 6 to 12 weeks. The simply best volume generating filler is your own, autologous fat. The difference, fat will look natural and it will be permanent when done properly. I hope this helps and good luck from Leonard Grossman MG organic plastic surgery

What’s another alternative to Sculptra, other than filler, if you have an autoimmune disease like POTS?

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What’s another alternative to Sculptra, other than filler, if you have an autoimmune disease like POTS?

Answers (3)

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Everything you need to know about Sculptra

Our mission is to create a world where every investment in modern beauty is Worth It.