Platelet-rich plasma (PRP) injections are claimed to stimulate the growth of tissue in the area into which it is injected. Since it is derived from your own blood, there are no tissue "rejection" concerns or worries about the need for immunosuppressive drugs.However, there is no credible scientific evidence that normal breast tissue growth can be stimulated in this way, or that breast cancer will NOT be stimulated. So much for "natural."Even fat grafts or fat-derived "stem cells" have not yet been proven to be safe for injection into breasts, despite many plastic surgeons (and lots of wanna-be "cosmetic surgeons" who are not fully trained and ABPS-certified plastic surgeons) practicing this technique. Many, many questions still need to be answered, IMHO, about fat grafting into breasts (including the fact that about half of the injected fat dies and can turn into scars, lumps, or calcifications that interfere with mammography.)There is a reason that breast implants remain the best and most time-tested medical devices in the entire marketplace--they have been exhaustively studied, and all lay press and media fueled anxieties aside, silicone and saline breast implants are safe, and your best option for breast augmentation. They require NO "maintenance, do NOT "wear out" and need replacement in ten years, and do NOT require periodic MRI scans as the FDA "recommends." This recommendation is based on previous-generation silicone implants that COULD leak a had a high(er) rupture rate--present-generation cohesive silicone implants do NOT leak, and are so extraordinarily strong they rarely rupture (when they do, I believe this is due to surgeon mishandling or damage, NOT manufacturer defect.) Properly-overfilled saline implants have a low leak rate, but this is not zero, and these implants can require replacement in a percentage of cases, one reason that silicone (newest generation of cohesive) implants are the most commonly used ones worldwide, not just here in the US.Lastly, "upper pole fullness" is not something achieved by PRP, fat grafting, or even properly-performed breast implants--upper pole fullness is the province of a good push-up bra, and having adequate breast volume (size) to have something to actually push up. That full upper pole look you seem to be desirous of is too-often caused by capsular contracture tightening around implants, and this yields hard, unnatural, and sometime painful breasts. You may like the "look," but you (and your partner) will definitely NOT like the "croquet ball in the vest pocket" feel! Get soft breasts and move them any way you wish, but don't wish for capsular contracture!If true safety is what you and your husband seek, then breast implants are your BEST answer. Honest. If you still don't believe me, you need more information, as I've spent a lifetime of medical education and a full career studying this, not just spare-time online research. Please read my Comprehensive Guide to Breast Augmentation for more information by clicking on the web reference link below. Best wishes! Dr. Tholen