Could spironolactone work with antibiotics?

Question

I was on spiro for many years, worked great, except that makes me extremely tired and lowers my blood pressure a lot. Changed to Seysara, works great except my skin, hair get greasy, sometimes is hard on my gut, is expensive and I dislike the idea of long term use. My doctor has been great but I’m looking for other opinions. Could I mix those two in minimum doses? I’m 145lb 5,5 ft. What could be a minimum dosage that keeps my skin somehow clear, while keeping my energy and not breaking the bank?

Anna Chacon, MD, FAAD · Answer

Spironolactone is a medication that is primarily used to treat conditions like high blood pressure and heart failure. On the other hand, antibiotics are used to treat bacterial infections.
There are no known direct interactions between spironolactone and most antibiotics, meaning they can often be used together safely. However, each individual's health status, other medications, and overall treatment plan may influence this.
There are a few antibiotics, such as trimethoprim, that could potentially increase the risk of hyperkalemia (high potassium levels in the blood) when taken with spironolactone. This is because both medications can increase potassium levels, and taking them together may cause this level to rise too high.
As always, it's crucial to discuss all medications, including antibiotics, with your healthcare provider before starting or stopping any medication. They can provide guidance based on your specific health history and current medications.

Could spironolactone work with antibiotics?

Answers (1)