How long does it take for Hyaluronidase to take full effect?

Question

I got Hyaluronidase injected to reduce some uneven restalyne filler that shifted And formed above my upper lip. How many hours/days does it take for the filler to be completely dissolved by the enzyme, and if I have a bump where the Hyaluronidase was injected is it a bruise or some filler left? Should I try massaging it to bring it down? How long do you have to wait to be able to massage your lip after the enzyme was injected without being at risk or moving things around. Thanks for your help!

Raffy Karamanoukian, MD, FACS · Answer

Longterm filler problems include migration, edema, and nodularity. Filler migration and permanence is a very common problem because there are many different types of HA fillers on the market and each is specified for a specific part of the face. Use of highly cohesive fillers on thin skin may cause swelling and nodularity. If patients have filler migration or nodules, we recommend a combination approach of filler reversal with enzymes Hylenex and Hyaluronidase in different strengths to dissolve the filler. We may also need to add Kenalog to the mix in order to reduce fibrous tissue. If the filler does not dissolve, it either means the filler is not HA material or we need more enzyme. The HA reversal can be combined with other lasers and skin treatments at the same time, and it usually (usually) does not affect adjacent tissue.

Best, 
Dr. Karamanoukian 
Realself100 Surgeon

Shaun Patel, MD · Answer

The hyaluronidase should start to work immediately but may take up to two weeks to finish dissolving the filler. At that time, you may need more hyaluronidase if some filler is still left over.

Darryl J. Blinski, MD · Answer

Using Ha dissolver like hyaluraonidase is a very experienced injector technique. It is not just an injection alone, it is dose dependent, multiple sessions over a few weeks, and expensive.

Leonard Grossman, MD · Answer

Even though hyaluronidase starts to work immediately, it takes up to two weeks for the full result to become obvious. Good luck from New York City

How long does it take for Hyaluronidase to take full effect?

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How long does it take for Hyaluronidase to take full effect?

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