How long does it take for Hyaluronidase to take full effect?

Longterm filler problems include migration, edema, and nodularity. Filler migration and permanence is a very common problem because there are many different types of HA fillers on the market and each is specified for a specific part of the face. Use of highly cohesive fillers on thin skin may cause swelling and nodularity. If patients have filler migration or nodules, we recommend a combination approach of filler reversal with enzymes Hylenex and Hyaluronidase in different strengths to dissolve the filler. We may also need to add Kenalog to the mix in order to reduce fibrous tissue. If the filler does not dissolve, it either means the filler is not HA material or we need more enzyme. The HA reversal can be combined with other lasers and skin treatments at the same time, and it usually (usually) does not affect adjacent tissue.

Best,
Dr. Karamanoukian
Realself100 Surgeon

The hyaluronidase should start to work immediately but may take up to two weeks to finish dissolving the filler. At that time, you may need more hyaluronidase if some filler is still left over. 

Using Ha dissolver like hyaluraonidase is a very experienced injector technique. It is not just an injection alone, it is dose dependent, multiple sessions over a few weeks, and expensive. 

Even though hyaluronidase starts to work immediately, it takes up to two weeks for the full result to become obvious. Good luck from New York City