Different fillers last different lengths of time, depending on their properties of degradation and the individual patient's body chemistry with respect to that particular filler. The same is true of a filler's propensity to migrate: its likelihood is variable depending on the product, where it was injected, and the individual patient's body chemistry response to that filler. In general, the hyaluronic acids break down fastest, and the more highly-cross-linked hyaluronic acids tend to break down slower than the less-cross-linked ones. The hyaluronic acids act as a sponge, taking on water and swelling, to fill in a defect or hollow. That is their mechanism of action. The only collagen production is due to the needle injury from the needle used to inject them. The 3 most common Biostimulatory agents injected into the face in the USA act by triggering 2 kinds of collagen (each). They include Radiesse, Sculptra, and BellaFill. Part of the volumization and improvement in skin texture is, therefore, related to the body's response to the biostimulatory agent: Collagen production! Radiesse (Calcium hydroxylapatite), a biostimulatory agent, tends to last longer than the hyaluronic acids, and triggers synthesis of two types of collagen, and actually allows collagen and muscle fibers to integrate and grow into the spherules of product. Sculptra (polylactic acid- which is a liquified, crystallized form of a commonly used dissolvable surgical suture material), another biostimulatory agent, acts longer still, so long as the product is injected in a series of sessions (much like a vaccine). And BellaFill, (PMMA, poly-methyl-methacrylate), which comes suspended in a medium that contains bovine protein, lasts forever!!! PMMA is a material with an excellent track record, incidentally, for its safety and biocompatibility, having been used as a material to replace the eye lens (after cataract removal) for generations!! As we say, you can move back the hands of time, but you cannot stop them! So with all these products, signs of aging will eventually show, since aging is a continuous process. Thank you for the interesting notes you shared! I love the science of all this, and the plethora of wonderful ways in which we can apply it to help others.