Regarding PRP for hair loss; what is the difference between injecting PRP versus using PRP with microneedling on the scalp?

The study performed with the Eclipse system used the injection technique.  Most physicians use the injection technique now.  The microneedle technique makes sense and is certainly an option, but there is no study that I am aware of which directly compares the two techniques to see which is better.

This needs an in-person evaluation. I suggest seeing a hair loss expert now to evaluate and go over your condition and provide you information about your best treatment options. There are great non-invasive options like prp/progesterone and/or hair transplantation. See an expert. Best, Dr. Emer

For years, micro-needling was the  technique to deliver PRP. During that time, increases in the density of hair growth and size of hair shaft average between 4 and 10%. Since the subdermal injection technique has been utilized, Studies have shown between 25 and 30% increase in hair density and 25 to 30% increase in size of hair shaft . (Haushaur) . Injection of the PRP in the subdermal or deep dermal area puts the PRP closer to the base of the follicular unit where it can be effective. It also allows for greater spread of the growth factors. 
Jeff Rapaport MD FAAD
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As with many of the procedures utilizing PRP, there is no absolute standard of care. Many will apply PRP topically allowing for absorption via portals created by microneedling while others will inject and still others will employ a combination of both techniques. Ultimately, the goal is to deliver growth factors to the site of injury/inflammation promoting rejuvenation.
Without good randomized data, it remains unclear which approach is best. It is likely that the difference between the approaches is negligible as long as the PRP is delivered where it is needed most (either topically or via direct injection or both).
As always, discuss your concerns with a board certified plastic surgeon (ABPS).Donovan Rosas MD
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Surgery, American Society of Plastic Surgeons
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Hello and thank you for your question. Personally I use and prefer injections because it goes deeper into the skin. Depending on where you get PRP, not everyone can administer the injections. I’m not sure if there is research showing these results, but it is my preference. Best wishes.Dr. T

In order to get the most effective treatment, it’s important to get deep enough to treat the hair follicle and Prp injections get to that necessary depth. Microneedling treats more superficially and would not get to the required depth to get the best results,

I do both.  I definitely feel that injections are required to have the growth factors reach the hair follicles; which are below the skin. This "jump starts" the follicles, to maximally produce hair.  I also use microneedling (with topical PRP sprinkled)  to create microscopic wounding of the scalp; to encourage migration of more growth factors into this area; to "help heal" the wounded skin.  That way  you get the injected PRP growth factors plus additional , recruited growth factors.

Microneedling is great for resurfacing the skin of the face, neck or a scar. It is not effectively administering PRP to where the hair follicle growth starts. The gold standard for hair regrowth is to use a cross hatching subdermal injection technique. 

In our practice each patient is required to come in for full evaluation including a hormone panel, and analysis . Micro needling has been part of our protocol to further simulate the hair follicular growth. most doctors that are doing this type of procedure should be doing both injection of PRP  with micro needling. Research shows that both are effective but together the outcome is doubled. I hope this helps

I have not seen any research that shows a comparison between these two modalities. Like you, I would love to see one