How much hyaluronidase would it take to remove one syringe of Voluma and one Vollure?

Question

2 ml of voluma/ vollure. highly cross linked.i have two ml in various areas of the face: used vitrase. 1st time 180 full strength, 2nd time 70 full strenght some areas, 3rd time, 180 full strength. Negligible results. went to another dr. 200 units diluted in 5 syringes. if the other times, results were negligible, w the dilute vitrase i got No results at all. i am not trusting these drs using the right dosages. are the dosages too low for two ml of voluma? how many units/session to take care of 2 ml

Jason Emer, MD · Answer

For unique cases where a variety of modalities could be used to treat the condition, I would suggest an in-person or virtual consultation to develop a custom and effective treatment plan.  It is difficult to precisely define the best option without collecting the same information. I suggest reaching out to an expert for a consultation with surgical and non-surgical methods to get a comprehensive option. Best, Dr. Emer.

Nelson Castillo, MD · Answer

Thank you for sharing your excellent question. Unfortunately there is no exact dosing of Vitrase to dissolve a specific amount of filler, and with both Voluma and Vollure I would seek a series of treatments until your desired results are obtained.  If Vitrase does not seem to work, consider Hylenex.  Hope this helps.

Dmitriy Schwarzburg, MD · Answer

It depends on the amount of filler that was injected. It also depends on the depth of injections. Look for a board-certified and experienced physician to help you with this problem.

Alex Eshaghian, MD, PhD · Answer

Thank you for your question victoriaxoxoxo. I understand your concern. Fillers such as Voluma and Vollure are used to restore
lost volume in and enhance the appearance of the face.It is difficult to make an assessment without a
formal exam in the office where I can view the skin in multiple angles. However,
I hope the information provided here is useful.Hyaluronic acid fillers such as Voluma and Vollure have higher safety than other fillers because they can be dissolved in the event of a complication or if the results are not as desired. Hyaluronic acid fillers can be dissolved with hyaluronidase, examples include Vitrase and Hylenex. Such treatments are considered off-label as there have not been studies to evaluate the safety and efficacy of this treatment. That being said, hyaluronidase is routinely used. There are no guidelines as to how much hyaluronidase is required to dissolve fillers. However some physicians find that using 150 units of hyaluronidase (the amount in one vial of Hylenex) is sufficient to dissolve one syringe of hyaluronic acid. Some of the newer fillers such as Voluma and Vollure (as well as Volbella) use a new technology called Vycross. This means that the chemistry is changes to allow for patients to enjoy their results for longer. They also combine both high and low molecular weight hyaluronic acid. Some find that more hyaluronidase is required to dissolve these products. In such cases a hyaluronidase treatment is performed and the results are assess approximately two weeks later (except in the case of occlusion). At that point a repeat treatment may be performed if the desired results are not achieved.Please consult with a doctor for specific
recommendations.  Good luck!

How much hyaluronidase would it take to remove one syringe of Voluma and one Vollure?

Answers (4)

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