Hello. Both products are thicker Hyaluronic acid based products that are best used in the mid face and in particular the cheeks.The one glaring difference is price. In most cases in Los Angeles, Voluma is priced $200 - $300 more per CC than Restylane Lyft (Perlane). It is sold at a higher price point because it is marketed to last longer. We do have concerns about the marketed longevity for Voluma because of the way in which the trials were conducted by Allergan. When Voluma conducted their trials, the average patients was injected with 6.5 CC's of Voluma. There are very few patients in our market that ever get this much product because it would cost $4,500 - $6,000. In addition, only 50% of patients reported seeing trace amounts of product left at 2 years.In the end, what this means is that to have any chance of achieving a 2 year duration, the patient would have to be injected with 4, 6 or 8 CC's of product. Given that we know we can achieve 9-12 month duration with Perlane (Lyft), we recommend our patients use Lyft instead of Voluma.