I have large nostrils, but I don't want to get another rhinoplasty. Can dermal filler be placed in the nose/nostrils?

The nostrils are very thin soft structures of the nose. Fillers add volume and will not make things smaller. Therefore, placing filler within the tissue may result in a thick appearning nostril, contour abnormalities, or permanent injury to the tissue. It is best to have an in-office examination to determine the most effective and SAFEST treatment option to achieve your goals. Hope this helps!Johnson C. Lee, MD Plastic Surgery@Drjohnsonlee

Pictures and an in-office visit would be required to accurately answer you question.  Given that, you seem to be asking if putting fillers in the soft tissues around the nasal opening would help to make your nostrils smaller.  This is unlikely.  There are a few things that can be done with fillers to make the nostrils smaller but typically a revision rhinoplasty will be needed.  Often, to narrow the nostrils, this is a procedure that can be simply done in the office under local anesthesia.  Consult with a board-certified expert.  Best wishes.