If Botox drips into my eye during injection of my forehead, can it cause severe headache and flu-like symptoms?

This is going to be a difficult question to answer.  I am not aware of any studies looking into the effect of topical amount of Botox in the eye.  As a facial plastic surgeon, I think it would be unlikely that a small drop of Botox in the eye could cause these symptoms.  

It is unlikely that a small drop of botox in the eye would cause such systemic symptoms.  It would be best to consult your primary care physician if you are experiencing flu-like symptoms.

I do not believe that your symptoms are from the Botox dripping into your eye.  The cornea is quite avascular, and even in inner (conjunctival) surface of your eyelid would be unlikely to absorb Botox.  If you had difficulty opening your eyelids, I could perhaps attribute it to local effects of Botox, but I suspect that your symptoms are due to something else, perhaps the flu!Good luck,Dr. Harkaway

I do not think this is going to harm you.  We had this happen once during a training session and our patient was fine. Certainly the dose of Botox even if you absorbed the entire drop or two (or more)should be lower than a dose that would cause harm since the nurse probably only had a reasonable dose drawn up to administer. As to whether the headache is related I am uncertain. 

After Botox is injected, it can migrate, sometimes for great distances. It can then cause symptoms such as those you describe. Please Google "Botox side effects" to verify this. While Botox may not act topically on skin, the eye may be a different matter all together. I am not aware of any reports of occular absorption of Botox, but you might want to google this as well. In any case, these symptoms should fade as the Botox starts to wear off.                   jlr