Has there been any reports on systemic reactions after having Silikon 1000 injected?

Question

I need my nose smoothed out after a nose job and this is my drs recommendation but I'm wary as I have hashimotos and don't want my bisy to react badly.

J. Timothy Katzen, MD, FACS · Answer

Hello Lindalou22, and thank you for your question about Silikon 1000 and the possibility of systemic reactions.

Yes, there have been reports of systemic reactions following Silikon 1000 injections, particularly in individuals with underlying autoimmune conditions such as Hashimoto's thyroiditis. Silikon 1000 is a permanent filler made of liquid silicone, and while it might seem like an easy fix for smoothing out irregularities, its permanence and potential to trigger chronic inflammation or immune responses make it a risky choice—especially for someone with a pre-existing autoimmune disorder.

Silicone can act as a foreign body in the tissues, and over time, it may provoke a condition known as ASIA syndrome (Autoimmune Syndrome Induced by Adjuvants). This condition occurs when the immune system reacts to the silicone, leading to symptoms such as fatigue, joint pain, swelling, and systemic inflammation. Even if you do not experience an immediate reaction, the presence of silicone in the body increases the risk of delayed hypersensitivity or chronic inflammatory responses years after the injection.

In addition to systemic risks, silicone injections can also cause localized complications, such as migration, granuloma formation, and scar tissue buildup. These issues are particularly concerning in delicate areas like the nose, where precise structure and contour are crucial. If complications arise, removing the silicone is an invasive and complex process that may result in scarring or deformities.

Given your autoimmune condition and concerns about systemic reactions, I strongly recommend avoiding Silikon 1000. Safer alternatives, such as hyaluronic acid fillers like Restylane or Juvederm, are temporary, reversible, and far less likely to provoke an immune response. If a more permanent solution is desired, consulting with a board-certified plastic surgeon about revision rhinoplasty is a better option. This approach avoids the risks associated with permanent fillers and allows for a more predictable and controlled result.

I hope this information helps clarify the risks associated with Silikon 1000 and guides you toward a safer option for your needs. Please consult with your doctor and an experienced plastic surgeon to make an informed decision.

Sincerely,
J. Timothy Katzen, MD

Raffy Karamanoukian, MD, FACS · Answer

Silicone biopolymers can cause severe longterm complications including inflammation and nodule formulation. Although results are longer-lasting that Juvederm or Restylane, long-acting fillers should be avoided.  
Bellafill, Artefill, and PMMA are known to cause granulomas and permanent nodules with swelling. This is not the case for everyone. Silicone biopolymers can also cause similar chronic inflammatory conditions. 
In my practice, I specialize in the removal of Bellafill and Artefill injections, in addition to silicone biopolymers, from the face and body. Initially, treatments are non-surgical with corticosteroids and immune modulators. If unable to be corrected, we can also perform surgery in some cases. 
Silicone biopolymers can also be removed from the body if there are signs of migration or inflammation. All of these filler-types should be removed as early as possible. 
Lastly, our office is conducting ongoing studies of plasma-assisted corticosteroid application, which allows for diffusion of the treatment medication in superficial tissue without causing atrophy. 
Best, 
Dr. Karamanoukian 
Realself100 Surgeon

Eric M. Joseph, MD · Answer

To my knowledge, there are no disease processes associated with microdroplet Silikon1000 injections. In fact, we have used Silikon1000 in patients with autoimmune disorders without incident. Hope this helps. Dr Joseph

Lawrence Kass, MD · Answer

I have used Silikon 1000 extensively for at least the last ten years and am not aware of ANY systemic reactions and very, very few local reactions too.  I believe that it is an ideal filler for someone looking for a permanent solution to a filler problem.  That said, with your history of an autoimmune problem, it might be wise to avoid a permanent filler for your problem.  Good luck!

Robert Kotler, MD, FACS · Answer

I am not aware of any.  One interesting fact is that Silikon-1000  should be familiar to everyone's body because all hypodermic needles used for various injections are coated with it.  If a patient has any qualms about ever developing a reaction to it, we recommend a "test" whereby a tiny droplet is placed behind the ear and that area is observed for two months.  Should there be any unusual reaction, it would suggest that the patient is hypersensitive and therefore should not have the filler.  I have never seen a positive reaction.

Has there been any reports on systemic reactions after having Silikon 1000 injected?

Answers (5)

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