Hello Lindalou22, and thank you for your question about Silikon 1000 and the possibility of systemic reactions. Yes, there have been reports of systemic reactions following Silikon 1000 injections, particularly in individuals with underlying autoimmune conditions such as Hashimoto's thyroiditis. Silikon 1000 is a permanent filler made of liquid silicone, and while it might seem like an easy fix for smoothing out irregularities, its permanence and potential to trigger chronic inflammation or immune responses make it a risky choice—especially for someone with a pre-existing autoimmune disorder. Silicone can act as a foreign body in the tissues, and over time, it may provoke a condition known as ASIA syndrome (Autoimmune Syndrome Induced by Adjuvants). This condition occurs when the immune system reacts to the silicone, leading to symptoms such as fatigue, joint pain, swelling, and systemic inflammation. Even if you do not experience an immediate reaction, the presence of silicone in the body increases the risk of delayed hypersensitivity or chronic inflammatory responses years after the injection. In addition to systemic risks, silicone injections can also cause localized complications, such as migration, granuloma formation, and scar tissue buildup. These issues are particularly concerning in delicate areas like the nose, where precise structure and contour are crucial. If complications arise, removing the silicone is an invasive and complex process that may result in scarring or deformities. Given your autoimmune condition and concerns about systemic reactions, I strongly recommend avoiding Silikon 1000. Safer alternatives, such as hyaluronic acid fillers like Restylane or Juvederm, are temporary, reversible, and far less likely to provoke an immune response. If a more permanent solution is desired, consulting with a board-certified plastic surgeon about revision rhinoplasty is a better option. This approach avoids the risks associated with permanent fillers and allows for a more predictable and controlled result. I hope this information helps clarify the risks associated with Silikon 1000 and guides you toward a safer option for your needs. Please consult with your doctor and an experienced plastic surgeon to make an informed decision. Sincerely, J. Timothy Katzen, MD