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There are some studies that show that there is a production by your own body of new collagen as a result of injection of the hyaluronic acid. Whether this is related to the trauma and inflammation after needle injection, or the product being injected is not fully clear. The Juvederm itself is not permanent.
All HA (hyaluronic acid) fillers are reabsorbed over time, though how long they last depends on where they are placed and certain variations within the products. For example, placement in the cheeks usually lasts longer than in the lips. However, all fillers do elicit some response in terms of collagen formation so there may be some residual effect due to that.
Juvederm (and Restylane) may last longer in some individuals than others, but it will not be permanent for anyone. These products are eventually broken down, but in some areas they may persist for up to two years.
No, it is not possible for Juvederm or other Hyalauronic Acids to permanently stay in the system because these products are eventually broken down and reabsorbed by the body. The rate at which it is broken down is different for each person so some people may notice that Juvederm lasts 5 months, while others feel like it lasts 7 months. Movement of the muscle and tissue also affects the rate at which fillers last. Areas that move often, such as the lips, will not retain Juvederm as long as areas with less movement, such as the nasolabial folds. Having said this, I have noticed that some patient who get facial fillers (including Juvederm) seem to build up some connective tissue in the area of the injection, which might decrease the need for injections in the future. While this can happen, patient should not count on that outcome and should assume that their fillers are absorbable. I hope this helps!
Juvederm is a hyaluronic acid filler that is absorbable over time. The ultra plus is reported to last 9 months to a year. I suppose in some cases of very superficial injection, it may last longer, but it is not permanent.