No, it is not possible for Juvederm or other Hyalauronic Acids to permanently stay in the system because these products are eventually broken down and reabsorbed by the body. The rate at which it is broken down is different for each person so some people may notice that Juvederm lasts 5 months, while others feel like it lasts 7 months. Movement of the muscle and tissue also affects the rate at which fillers last. Areas that move often, such as the lips, will not retain Juvederm as long as areas with less movement, such as the nasolabial folds. Having said this, I have noticed that some patient who get facial fillers (including Juvederm) seem to build up some connective tissue in the area of the injection, which might decrease the need for injections in the future. While this can happen, patient should not count on that outcome and should assume that their fillers are absorbable. I hope this helps!