Does Juvederm VOLUMA Promote Collagen Production?

Voluma is a hyaluronic acid filler, and the main way that it works, is via the hyaluronic acid being part of your skin and helping to provide structure.  Although recent evidence indicates that HA fillers probably do stimulate minor collagen production, probably as a result of the fibroblasts (collagen-producing cells) responding to being stretched, I would not consider this to be a very prominent part of how they work. So, the answer to your question is that technically, voluma probably does promote collagen production, but not to the extent that it would make a noticeable difference.  If you like the result you had during the period when you had swelling, you would probably like the effect of additional volume.

Voluma, like all hyaluronic acid fillers, acts as a natural gel in skin to improve volume and appearance.  Several studies have demonstrated that fillers can get replaced by collagen over a long period of time.  Authors Wanik and Issa published one such study in Journal of Dermatol Surg describing increases in collagen fibers at 3 and 9 months.  Experienced injectors can also tell how the skin looks and feels different in patients with facial filler use which in part may be due to collagen formation.

Voluma can definitely cause some initial swelling post injection and as the swelling subsides over the next week or so, the result can seem less dramatic. Voluma has not been shown to promote significant collagen production. Voluma is supposed to last about 2 years. If you feel that you need more filler or you have questions about the type of filler used and what your other options are based on your needs, definitely contact your injector.

Great question! Voluma results are immediate but are often exaggerated by post-injection swelling. It’s important to understand that when you leave the doctors office after being injected, you are swollen. Often times this swelling is easy to mistake as the results of the Voluma injection. Taking into consideration that you were injected one week ago, the timing lines up for your swelling to have just subsided, which would create the illusion of the results looking “deflated”. Voluma is a hyaluronic acid and does not have the same collagen building properties as other products like Sculptra. The results of Voluma have been shown to last for up to 2 years, but if you have any concerns I would recommend contacting your injecting physician so that they can follow up with you.

I have been using Juvederm Voluma for over 1.5 years and have not seen evidence of collagen stimulation.  This product is not designed to stimulate collagen.  It provides natural long lasting results.  Studies on Restylane have shown that there can be some collagen stimulation with the use of HA's but this is less common and not the reason for injecting Voluma.Its not unusual to get some mild swelling for a days post injection which can persist for up to 2 4 weeks.  I will therefore wait to do any boost injections at the 1 month follow up visit.  What you see at 1 month should persist up to 2 years.Ran Y. Rubinstein, MD
200 Stony Brook Court, Newburgh, New York
Board Certified Facial Plastic Surgeon (ABFPRS)American Society forLaser Medicine & Surgery (ASLMS)
Clinical Professor New York Presbyterian Hospital
National Education Faculty (physician trainer) for:
Allergan (Botox, Juvederm, Voluma), Galderma
(Scultpra, Restylane, Silk), Cynosure (Cellulaze, Precision Laser Lift)
& Solta (Fraxel, Thermage)Zeltiq( CoolSculpting)

I don't believe that Voluma or any of the other HA fillers create enough local inflammation to induce collagen formation. They provide volume and are temporary fillers.

There have been some
studies that have shown that hyaluronic acid fillers may promote collagen
production, however, these are preliminary. It is reversible and very safe.
Voluma has some residual effect for up to 2 years according to its pivotal FDA
studies.

Voluma is not a stimulatory filler, but a volume filler. Although there is likely some mild collagen production, this is not the main mechanism of action of Voluma. Our office specializes in Voluma and Juvederm facial filler injections in Los Angeles. Raffy Karamanoukian MD FACS

Hi cmcm,Voluma is a thick hyaluronic acid filler.  You get what you see after proper placement of Voluma.  It is not dependent on collagen production over time.  If it is not injected in the proper place, then there can be initial swelling and a full appearance that is temporary and gone once the swelling has resolved.  Unfortunately I cannot support the claim that your Voluma will look better as time passes.  Good luck and be well.Dr. P

Based on your description, it seems like you may have had Sculptra and not Voluma. Voluma is instantaneous and only swells for a few days (and would not deflate). Sculptra promotes collagen building, Voluma does not.